Independent health economics & outcomes research
Evidence that holds up
when it is challenged.
Twenty-five years designing HEOR and RWE studies across payer, provider, and claims data — protocol through interpretation, for commercial, medical affairs, and market access teams.
Hover the curve, or focus it and use the arrow keys, to read either arm.
Fig. 01 / Survival estimate
24-month follow-up
Two arms, separating from month 6 and not converging. Illustrative data.
01The record
- 25+
- years in HEOR, RWE, and outcomes research
- 50
- publications, abstracts, and posters, 2003–2022
- 15
- full publications, including JAMA and Circulation
- 12
- therapeutic areas in the published record
Evidence is only useful when someone can defend it.
A result that cannot survive a payer's methodologist is not a result. We design for the challenge that comes after the readout — which is why feasibility, the analysis plan, and the interpretation are all done by the same senior team.
02What we do
01
Evidence generation
A protocol, an analysis plan and a result that survives challenge — with feasibility settled before any of it is written.
- Study design and feasibility assessment
- Protocol development
- Survival analysis
Fig. 02 / Adjusted hazard ratios
95% confidence interval
Illustrative data.
02
Real-world data analytics
Cohorts, models, and the code behind them, so the analysis is reproducible rather than a black box.
- SQL extraction across Hadoop, Teradata, and TOAD
- Analysis in SAS and SPSS
- Logistic regression and ANOVA
Fig. 03 / Participant flow
mSToPS randomized trial
Steinhubl et al., JAMA 2018.
03
Access & value strategy
The value case built in the terms a plan actually evaluates, by people who have sat on the payer side of the table.
- Value proposition development
- Value-based and outcomes-based contract design
- Care management program design
Fig. 04 / Cost-effectiveness plane
Bootstrap replicates vs. threshold
Illustrative data.
03Data coverage
Payer, provider, and claims data — for twenty-five years.
If your question sits in one of these sources, we have almost certainly answered a version of it before.
Payer
- Medical claims
- Eligibility
- Formulary
Provider
- EMR
- EHR
- Registry
Claims & pharmacy
- Pharmacy Rx
- Medical
- External lab
04RWE Synopsis
AI-assisted evidence.
Human-reviewed conclusions.
Synopses drafted in hours and reviewed by the researchers who would otherwise have written them. The model drafts; a person signs.
- 01
Feasibility
- 02
Retrospective
- 03
Pragmatic outreach
Human reviewRequired at every stage, before any output leaves the system.
Start with a conversation about the question you are trying to answer.
A 30-minute call with a senior researcher. No sales team.